Tag: dna

In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disruption of gene transcription and cell function are so similar to those seen in cellular aging, or senescence, that the […]

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Speeding up directed evolution of molecules in the lab

Natural evolution is a slow process that relies on the gradual accumulation of genetic mutations. In recent years, scientists have found ways to speed up the process on a small scale, allowing them to rapidly create new proteins and other molecules in their lab. This widely-used technique, known as directed evolution, has yielded new antibodies […]

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