Tag: aging

A brain circuit in the thalamus helps us hold information in mind

As people age, their working memory often declines, making it more difficult to perform everyday tasks. One key brain region linked to this type of memory is the anterior thalamus, which is primarily involved in spatial memory — memory of our surroundings and how to navigate them. In a study of mice, MIT researchers have […]

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Aging Brain Initiative awards fund five new ideas to study, fight neurodegeneration

Neurodegenerative diseases are defined by an increasingly widespread and debilitating death of nervous system cells, but they also share other grim characteristics: Their cause is rarely discernible and they have all eluded cures. To spur fresh, promising approaches and to encourage new experts and expertise to join the field, MIT’s Aging Brain Initiative (ABI) this […]

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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state

In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disruption of gene transcription and cell function are so similar to those seen in cellular aging, or senescence, that the […]

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