Using a powerful single-molecule imaging method they developed, a research team from the Broad Institute of MIT and Harvard has unveiled a dynamic view of how some cancer-related proteins interact in living cells. The technique relies on highly stable nanoparticle probes that brightly illuminate individual molecules for long periods of time. The researchers used their […]
Read MoreTag: Proteins
Bringing AI-driven protein-design tools to biologists everywhere
Artificial intelligence is already proving it can accelerate drug development and improve our understanding of disease. But to turn AI into novel treatments we need to get the latest, most powerful models into the hands of scientists. The problem is that most scientists aren’t machine-learning experts. Now the company OpenProtein.AI is helping scientists stay on […]
Read More
Slice and dice
What if the Trojan horse had been pulled to pieces, revealing the ruse and fending off the invasion, just as it entered the gates of Troy? That’s an apt description of a newly characterized bacterial defense system that chops up foreign DNA. Bacteria and the viruses that infect them, bacteriophages — phages for short — […]
Read More
Study reveals “two-factor authentication” system that controls microRNA destruction
Cells rely on tiny molecules called microRNAs to tune which genes are active and when. Cells must carefully control the lifespan of microRNAs to prevent widespread disruption to gene regulation. A new study led by researchers at MIT’s Whitehead Institute for Biomedical Research and Germany’s Max Planck Institute of Biochemistry reveals how cells selectively eliminate […]
Read More
Building the blocks of life
Billions of years ago, simple organic molecules drifted across Earth’s primordial landscape — nothing more than basic chemical compounds. But as natural forces shaped the planet over hundreds of millions of years, these molecules began to interact and bond in increasingly complex ways. Along the way, something spectacular emerged: life. “Life is, to some degree, […]
Read More
MIT engineers design proteins by their motion, not just their shape
Proteins are far more than nutrients we track on a food label. Present in every cell of our bodies, they work like nature’s molecular machines. They walk, stretch, bend, and flex to do their jobs, pumping blood, fighting disease, building tissue, and many other jobs too small for the eye to see. Their power doesn’t […]
Read More
CryoPRISM: A new tool for observing cellular machinery in a more natural environment
The blobfish, once considered the ugliest animal in the world, has since had quite the redemption arc. Years after it was first discovered, scientists realized that the deep-sea creature appeared so unnervingly blobby only because it went through an extreme change in pressure when it was brought up to the surface. In its natural environment, 4,000 […]
Read More