Experts say that while nutrition studies are notoriously challenging to carry out, there is a compelling and ever-growing body of research that does suggest that some foods and diets may offer real benefits to an aging brain. So we spoke with two dozen researchers and pored over the research to better understand the links between diet and dementia.
Four pillars of a ‘brain-boosting’ diet
Scientists don’t yet know for certain what causes Alzheimer’s disease, the most common form of dementia. And there is currently no medication that can reverse it, said Dr. Uma Naidoo, the director of nutritional and metabolic psychiatry at Massachusetts General Hospital and the author of “This Is Your Brain on Food.”
“But,” she said, “we can impact how we eat.”
Research shows that people with certain conditions like heart disease, high blood pressure, obesity and diabetes are more likely than those without such conditions to experience age-related cognitive decline. And the risks of developing those conditions can be increased by poor diet and a lack of exercise, suggesting there are things you can do to lower the chances of developing dementia, Dr. Naidoo said.
Two diets in particular, the Mediterranean diet and the MIND diet — both of which encourage fresh produce, legumes and nuts, fish, whole grains and olive oil — have been shown in scientific studies to offer strong protection against cognitive decline.
One study, published in 2017, analyzed the diets and cognitive performance of more than 5,900 older U.S. adults. Researchers found that those who most closely adhered to either the Mediterranean diet or the MIND diet had a 30 to 35 percent lower risk of cognitive impairment than those who adhered to these diets less closely.
“Pretty much anything that will help keep arteries healthy will reduce risk of dementia,” said Dr. Walter Willett, a professor of epidemiology and nutrition at the Harvard T.H. Chan School of Public Health. And Dr. Ronald Petersen, a neurologist and the director of the Mayo Clinic Alzheimer’s Disease Research Center, agreed: “What’s good for the heart is good for the brain.”
One big change you can make to your diet, Dr. Naidoo said, is to “up your plant game.” Leafy greens are packed with nutrients and fiber, and some solid evidence has linked them with slower age-related cognitive decline.
The Facts Behind 5 Supplements
Collagen. Collagen, is one of the most abundant proteins in the body and helps form our skin, bones, muscles, tendons and ligaments. As we age, we naturally start reducing its production. Some studies show that taking collagen supplements can reduce signs of aging, increase bone density and improve joint, back and knee pain. But many of these studies are small and funded by the companies behind such products, increasing the opportunity for bias. Certain products also have flaws that reduce the likelihood of their efficacy: Topical creams, for example, are unlikely to make it into the deeper level of the skin where collagen is produced.
In one randomized controlled trial performed in Israel and published this year, for instance, researchers took brain scans of more than 200 people who had been split into three diet groups. They found that after 18 months, those who followed a “green” Mediterranean diet — one rich in Mankai (a nutrient-packed green plant), green tea and walnuts — had the slowest rate of age-related brain atrophy. Those who followed a traditional Mediterranean diet were close behind. Those who followed regular healthy diet guidelines — which was less plant-based and allowed for more processed and red meat than the other two diets — had greater declines in brain volume.
These neuroprotective effects were especially pronounced in people 50 and older.
Colorful fruits and vegetables
The more colorful the produce on your plate, the better the food usually is for your brain, several experts said.
In one 2021 observational study, researchers followed more than 77,000 people for about 20 years. They found that those with diets high in flavonoids — natural substances found in colorful fruits and vegetables, chocolate and wine — were less likely than those who consumed fewer flavonoids to report signs of cognitive aging.
The MIND diet specifically points to berries, good sources of fiber and antioxidants, as having cognitive benefits. One study published in 2012 looked at more than 16,000 people aged 70 and older for more than a dozen years. It concluded that older women who ate more blueberries and strawberries had delayed rates of cognitive decline: perhaps by up to 2.5 years.
“I don’t think there are miracle foods, but, of course, it’s really good to eat the fruits and vegetables,” said Dr. Allison Reiss, a member of the medical, scientific and memory screening advisory board at the Alzheimer’s Foundation of America.
“Fish is brain food,” said Dr. Mitchel Kling, the director of the memory assessment program at the New Jersey Institute for Successful Aging at the Rowan University School of Osteopathic Medicine.
One specific omega-3 fatty acid — docosahexaenoic acid, or DHA — found in cold-water, fatty fish, like salmon, is “the most prevalent brain fat,” said Lisa Mosconi, the director of the Alzheimer’s Prevention Program at Weill Cornell Medicine.
Our bodies cannot make enough DHA on their own, Dr. Mosconi said. “We have to provide it from the diet, which is a strong argument toward eating fish.”
According to Dr. Willett, about two to three servings per week will provide “virtually all the benefit.”
Nuts, whole grains, legumes and olive oil
Nuts and seeds have been repeatedly linked to slower cognitive decline.
In one 2021 review of 22 studies on nut consumption involving nearly 44,000 people, researchers found that those at high risk of cognitive decline tended to have better outcomes if they ate more nuts — specifically walnuts. However, the authors acknowledged some inconsistency among the studies and inconclusive evidence.
Another study, published in 2014, looked at about 16,000 women ages 70 and up between 1995 and 2001. Researchers found that women who said they consumed at least five servings of nuts per week had better cognitive scores than those who did not eat nuts.
Whole grains, as well as legumes, like lentils and soybeans, also appear to have benefits for heart health and cognitive function. In one 2017 study of more than 200 people in Italy aged 65 and older, researchers found an association between consuming three servings of legumes per week and higher cognitive performance.
And olive oil, a main component of both the Mediterranean and MIND diets, has strong links with healthy cognitive aging. One 2022 study of more than 92,000 U.S. adults found that higher intakes of olive oil were associated with a 29 percent lower risk of dying from neurodegenerative disease — and 8 percent to 34 percent lower risk of mortality overall — when compared with those who never or rarely consumed olive oil.
Dietary supplements may have little effect
According to the experts we spoke with, there is little to no evidence that dietary supplements — including fatty acids, vitamin B or vitamin E — will reduce cognitive decline or dementia.
“Supplements cannot replace a healthy diet,” Dr. Mosconi said.
One major study of about 3,500 older adults, for instance, concluded that taking omega-3 supplements, which are often marketed as supporting brain health, did not slow cognitive decline.
When it comes to supplements like fish oil, Dr. Willett said, you don’t need to “load up like a seal.” Instead, Dr. Petersen, of the Mayo Clinic, said, remember this pithy adage: “If it comes from a plant, eat it. If it’s made in a plant, don’t eat it.”