Bruno Petkovic is struggling with a shoulder injury and may be replaced in the side by Mario Gavranovic. Petkovic played a key part in the win over Tottenham so this could be crucial for the Croatians.
Orsic the hat-trick hero is fit to start and looking to build on a return of 12 goals in 26 appearances in major European competition for Zagreb since joining in 2018.
The 19-year-old defender Joško Gvardiol has recovered from his thigh injury and will be looking to start again, after having missed both matches against Tottenham. He has signed for Leipzig but it currently on loan at Dinamo until the summer.
Aside from this, Zagreb are expected to go with the same line up that proved successful in the second leg against Spurs.
As for Villarreal, the only known injury concerns are Pervis Estupinan and Vicente Iborra .
Dinamo Zagreb possible starting lineup:
Livakovic; Ristovski, Lauritsen, Theophile-Catherine, Franjic; Majer, Ademi, Jakic; Ivanusec, Gavranovic, Orsic
Villarreal possible starting lineup:
Asenjo; Foyth, Albiol, Torres, Pedraza; Chukwueze, Parejo, Capoue, Trigueros; Alcacer, Moreno